EML3

Across TCGA cell cohorts, EML3 mutation is significantly associated with the RNA expression of many other genes, with 286 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EML3-associated genes across cancer lineages are PPP2R5D, ZFAND4, and OR4X2. Each is linked with EML3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EML3-to-partner and partner-to-EML3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2R5D grouped by EML3-low versus EML3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EML3→partner) and Y-score (partner→EML3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP2R5D →	+0.696	+3.064	.001	.009	3	2
LARGE_INTESTINE	ZFAND4 →	+0.879	+3.364	.001	.002	3	2
SOFT_TISSUE	OR4X2 →	+0.024	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR9A2 →	+0.036	+4.417	<.001	.004	3	1
SOFT_TISSUE	MAGEB3 →	+0.039	+4.222	.003	.007	3	1
SOFT_TISSUE	PRR20B →	+0.032	+4.977	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 286 associations by consensus.

PPP2R5D by EML3 expression — LARGE_INTESTINE

Explore this box plot interactively →