EML2

Across TCGA patient cohorts, EML2 mutation is significantly associated with the RNA expression of many other genes, with 2,952 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EML2-associated genes across cancer lineages are IGHD3-16, CORT, and FERMT3. Each is linked with EML2 in more than 2 cancer types. Because this analysis shows association rather than direction, both EML2-to-partner and partner-to-EML2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD3-16 grouped by EML2-low versus EML2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EML2→partner) and Y-score (partner→EML2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IGHD3-16 →	+1.426	+2.240	<.001	.005	3	3
UCEC	CORT →	+0.332	+1.809	.001	.001	3	3
UCEC	FERMT3 →	+0.540	+2.839	.002	.001	3	2
UCEC	CENPU →	+0.598	+2.364	.001	.002	3	2
UCEC	AP1S3 →	+0.500	+3.000	<.001	<.001	3	2
COAD	JAKMIP1 →	+0.729	+3.425	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,952 associations by consensus.

IGHD3-16 by EML2 expression — COAD

Explore this box plot interactively →