EML1

Across TCGA patient cohorts, EML1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EML1-associated genes across cancer lineages are HER3, p38-MAPK_pT180_Y182, and Caspase-8. Each is linked with EML1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EML1-to-partner and partner-to-EML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3 grouped by EML1-low versus EML1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EML1→partner) and Y-score (partner→EML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HER3 →	+0.397	+1.700	.013	.040	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.319	-2.502	.019	.001	3	2
UCEC	Caspase-8 →	-0.190	-1.973	.019	.008	3	2
COAD	C-Raf →	+0.159	+1.882	.009	.031	3	2
UCEC	14-3-3_beta →	-0.074	-1.880	.023	.014	3	2
UCEC	MEK1 →	+0.375	+2.169	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

HER3 by EML1 expression — SKCM

Explore this box plot interactively →