EML1

Across TCGA cell cohorts, EML1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EML1-associated genes across cancer lineages are BPIFA1, OR12D2, and RNASE3. Each is linked with EML1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EML1-to-partner and partner-to-EML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFA1 grouped by EML1-low versus EML1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EML1→partner) and Y-score (partner→EML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BPIFA1 →	+0.995	+5.643	<.001	.002	3	2
BLOOD_Lymphoma	OR12D2 →	+0.063	+5.643	<.001	.002	3	2
CNS	RNASE3 →	+0.124	+4.169	<.001	.008	3	1
OVARY	GUCY2F →	+0.006	+4.263	.006	.002	3	1
OVARY	CCDC140 →	+0.416	+3.938	<.001	.005	3	1
OVARY	OR2M4 →	+0.055	+3.700	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

BPIFA1 by EML1 expression — BLOOD_Lymphoma

Explore this box plot interactively →