EML1

Across TCGA cell cohorts, EML1 mutation is significantly associated with the mutation status of many other genes, with 1,915 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EML1-associated genes across cancer lineages are MYO15A, BSN, and POR. Each is linked with EML1 in more than 4 cancer types. Because this analysis shows association rather than direction, both EML1-to-partner and partner-to-EML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO15A grouped by EML1-low versus EML1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EML1→partner) and Y-score (partner→EML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYO15A →	+2.115	+3.198	.009	.009	1	5
STOMACH	BSN →	+2.942	+4.025	.009	.009	1	4
CNS	POR →	+5.277	+4.459	.005	.005	1	4
UPPER_AERODIGESTIVE_TRACT	RTN4 →	+4.392	+4.954	.008	.008	1	4
UPPER_AERODIGESTIVE_TRACT	MARCHF7 →	+4.392	+4.954	.008	.008	1	4
LARGE_INTESTINE	LAMC3 →	+1.781	+3.602	.006	.006	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,915 associations by consensus.

MYO15A by EML1 expression — BLOOD_Leukemia

Explore this box plot interactively →