Across TCGA pan-cancer cohorts, EMILIN3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of EMILIN3’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where EMILIN3 RNA is repressed in tumor relative to normal tissue. In most cancer types EMILIN3 is over-expressed in tumor, although a few such as COAD and KIRP show the opposite, repressed pattern.
COAD, KIRP, and STAD are the cancer types where EMILIN3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EMILIN3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.