EMILIN2

Across TCGA patient cohorts, EMILIN2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMILIN2-associated genes across cancer lineages are EGFR_pY1068, Rab25, and 4E-BP1. Each is linked with EMILIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EMILIN2-to-partner and partner-to-EMILIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EMILIN2-low versus EMILIN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMILIN2→partner) and Y-score (partner→EMILIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.198	-1.584	.028	.019	3	2
UCEC	Rab25 →	-0.318	-3.169	.007	.018	3	2
SKCM	4E-BP1 →	+0.259	+1.700	.043	.043	3	2
SKCM	ER-alpha →	-0.194	-3.136	.013	.018	3	2
SKCM	Shc_pY317 →	-0.177	-2.205	.027	.010	3	2
LUAD	SF2 →	+0.161	+3.025	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by EMILIN2 expression — UCEC

Explore this box plot interactively →