EMILIN1

Across TCGA patient cohorts, EMILIN1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMILIN1-associated genes across cancer lineages are Cyclin-B1, eEF2, and EGFR_pY1068. Each is linked with EMILIN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EMILIN1-to-partner and partner-to-EMILIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by EMILIN1-low versus EMILIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMILIN1→partner) and Y-score (partner→EMILIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.595	+2.392	.002	<.001	3	3
COAD	eEF2 →	+0.440	+3.178	.002	.010	3	2
UCEC	EGFR_pY1068 →	-0.254	-2.000	.004	.003	3	2
UCEC	Notch1 →	+0.161	+2.009	.001	.005	3	2
UCEC	PCNA →	+0.205	+1.362	.007	.037	3	2
UCEC	Annexin_VII →	-0.104	-1.362	.034	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Cyclin-B1 by EMILIN1 expression — UCEC

Explore this box plot interactively →