Across TCGA pan-cancer cohorts, EME2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of EME2’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where EME2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EME2 is over-expressed in tumor.
COAD, KIRC, and LIHC are the cancer types where EME2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EME2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.