EME1

Across TCGA patient cohorts, EME1 mutation is significantly associated with the RNA expression of many other genes, with 1,792 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EME1-associated genes across cancer lineages are LINC02165, ALDOA, and AP1S3. Each is linked with EME1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EME1-to-partner and partner-to-EME1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02165 grouped by EME1-low versus EME1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EME1→partner) and Y-score (partner→EME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC02165 →	+0.104	+4.289	<.001	.007	3	2
UCEC	ALDOA →	+0.530	+3.831	.002	<.001	3	2
UCEC	AP1S3 →	+0.718	+3.807	<.001	<.001	3	2
UCEC	CCSAP →	+0.545	+3.592	.009	.001	3	2
UCEC	TSR1 →	+0.468	+2.502	.005	.002	3	2
UCEC	PBK →	+0.963	+3.180	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,792 associations by consensus.

LINC02165 by EME1 expression — BLCA

Explore this box plot interactively →