EME1

Across TCGA cell cohorts, EME1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible EME1-associated genes across cancer lineages are AVP, TBC1D21, and OR10Q1. Each is linked with EME1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EME1-to-partner and partner-to-EME1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by EME1-low versus EME1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EME1→partner) and Y-score (partner→EME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.068	+4.217	<.001	.001	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR10Q1 →	+0.110	+3.920	.001	.005	3	1
LARGE_INTESTINE	OR52H1 →	+0.031	+4.347	<.001	.001	3	1
LARGE_INTESTINE	PFN3 →	+0.149	+4.882	<.001	<.001	3	1
LUNG_SCLC	REG3G →	+0.081	+3.523	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

AVP by EME1 expression — LARGE_INTESTINE

Explore this box plot interactively →