EMD

Across TCGA patient cohorts, EMD protein abundance is significantly associated with the RNA expression of many other genes, with 11,108 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible EMD-associated genes across cancer lineages are CXorf56, BRCC3, and TMEM185A. Each is linked with EMD in more than 5 cancer types. Because this analysis shows association rather than direction, both EMD-to-partner and partner-to-EMD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EMD versus CXorf56 in HNSC, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMD→partner) and Y-score (partner→EMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CXorf56 →	+0.874	+0.350	.001	<.001	3	6
BRCA	BRCC3 →	+0.487	+0.370	<.001	.002	3	6
COAD	TMEM185A →	+0.480	+0.162	<.001	<.001	3	6
OV	IDS →	+0.556	+0.291	.001	<.001	3	5
HNSC	OCRL →	+0.558	+0.328	<.001	<.001	3	5
HNSC	RBMX2 →	+0.607	+0.320	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,108 associations by consensus.

EMD vs CXorf56 — HNSC

Explore this scatter interactively →