EMD

Across TCGA cell cohorts, EMD RNA expression is significantly associated with the go_rna of many other GO terms, with 2,996 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible EMD-associated GO terms across cancer lineages are snRNA pseudouridine synthesis, Proton-transporting V-type ATPase complex assembly, and Mitotic spindle elongation. Each is linked with EMD in more than 10 cancer types. Because this analysis shows association rather than direction, both EMD-to-partner and partner-to-EMD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, snRNA pseudouridine synthesis grouped by EMD-low versus EMD-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EMD→partner) and Y-score (partner→EMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	snRNA pseudouridine synthesis →	+0.085	+0.819	<.001	.003	3	11
LIVER	Proton-transporting V-type ATPase complex assembly →	+0.152	+1.133	.003	.002	2	10
KIDNEY	Mitotic spindle elongation →	+0.214	+0.830	.003	.006	3	9
URINARY_TRACT	Spindle elongation →	+0.207	+0.917	<.001	<.001	3	9
KIDNEY	Mitotic spindle midzone assembly →	+0.214	+0.830	.003	.006	3	9
SOFT_TISSUE	Tail-anchored membrane protein insertion into ER membrane →	+0.070	+0.564	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,996 associations by consensus.

snRNA pseudouridine synthesis by EMD expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →