EMD

Across TCGA cell cohorts, EMD mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EMD-associated genes across cancer lineages are GUCA2A, KRTAP7-1, and TBC1D21. Each is linked with EMD in more than 1 cancer types. Because this analysis shows association rather than direction, both EMD-to-partner and partner-to-EMD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by EMD-low versus EMD-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMD→partner) and Y-score (partner→EMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GUCA2A →	+0.052	+5.969	<.001	.001	3	1
BLOOD_Leukemia	KRTAP7-1 →	+0.095	+5.539	<.001	.003	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	PFN3 →	+0.169	+4.467	<.001	.004	3	1
LARGE_INTESTINE	PYDC2 →	+0.108	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GUCA2A by EMD expression — BLOOD_Leukemia

Explore this box plot interactively →