EMC8

Across TCGA patient cohorts, EMC8 RNA expression is significantly associated with the mutation status of many other genes, with 13,714 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMC8-associated genes across cancer lineages are TP53, TTN, and ZNF536. Each is linked with EMC8 in more than 8 cancer types. Because this analysis shows association rather than direction, both EMC8-to-partner and partner-to-EMC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by EMC8-low versus EMC8-high in SKCM.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMC8→partner) and Y-score (partner→EMC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TP53 →	+2.121	+0.247	<.001	<.001	3	9
UCEC	TTN →	+1.001	+0.307	<.001	<.001	3	9
STAD	ZNF536 →	+2.584	+0.339	<.001	<.001	3	7
GBM	MUC16 →	+1.886	+0.256	.002	.001	3	6
CESC	FLG →	+1.955	+0.268	.002	.007	3	5
UCEC	PCDH11X →	+2.390	+0.458	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,714 associations by consensus.

TP53 by EMC8 expression — SKCM

Explore this box plot interactively →