EMC8

Across TCGA cell cohorts, EMC8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,156 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EMC8-associated GO terms across cancer lineages are Protein insertion into ER membrane by stop-transfer membrane-anchor sequence, Peptidyl-methionine modification, and mRNA alternative polyadenylation. Each is linked with EMC8 in more than 16 cancer types. Because this analysis shows association rather than direction, both EMC8-to-partner and partner-to-EMC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein insertion into ER membrane by stop-transfer membrane-anchor sequence grouped by EMC8-low versus EMC8-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EMC8→partner) and Y-score (partner→EMC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Protein insertion into ER membrane by stop-transfer membrane-anchor sequence →	+0.138	+0.759	<.001	<.001	3	17
LUNG_SCLC	Peptidyl-methionine modification →	+0.275	+0.730	.008	<.001	3	16
BONE	mRNA alternative polyadenylation →	+0.111	+0.879	.001	<.001	3	13
LIVER	Peptidyl-proline modification →	+0.142	+0.890	.001	<.001	3	13
BONE	Nucleic acid transport →	+0.088	+0.565	.006	.003	3	13
BONE	RNA transport →	+0.088	+0.565	.006	.003	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,156 associations by consensus.

Protein insertion into ER membrane by stop-transfer membrane-anchor sequence by EMC8 expression — BREAST

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