EMC6

Across TCGA patient cohorts, EMC6 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMC6-associated genes across cancer lineages are SMIM12P1, F8A2, and MLECP1. Each is linked with EMC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both EMC6-to-partner and partner-to-EMC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM12P1 grouped by EMC6-low versus EMC6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMC6→partner) and Y-score (partner→EMC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMIM12P1 →	+0.474	+4.398	.003	.006	3	1
UCEC	F8A2 →	+0.072	+4.694	<.001	.007	3	1
UCEC	MLECP1 →	+0.108	+5.226	.005	.003	3	1
UCEC	KRTAP23-1 →	+0.628	+5.302	<.001	.001	3	1
UCEC	RNU4-51P →	+0.575	+4.936	.006	.002	3	1
UCEC	RNU6-366P →	+0.532	+5.226	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

SMIM12P1 by EMC6 expression — UCEC

Explore this box plot interactively →