EMC4

Across TCGA pan-cancer cohorts, EMC4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated EMC4 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EMC4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EMC4 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where EMC4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.773	0.531	.004	46	view →
LSCC	DFS	Median	II,III,IV	0.829	1.000	.003	10	view →
CCRCC	DFS	Median	All	0.535	0.844	.028	6	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	4	view →
UCEC	DFS	Quartile	All	0.840	1.000	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

EMC4–HNSC (DFS)

Open the HNSC breakdown →