EMC4

Across TCGA patient cohorts, EMC4 RNA expression is significantly associated with the mutation status of many other genes, with 7,908 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMC4-associated genes across cancer lineages are TP53, ADAMTS12, and MUC16. Each is linked with EMC4 in more than 5 cancer types. Because this analysis shows association rather than direction, both EMC4-to-partner and partner-to-EMC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by EMC4-low versus EMC4-high in SKCM.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMC4→partner) and Y-score (partner→EMC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TP53 →	+1.542	+0.346	<.001	<.001	3	6
UCEC	ADAMTS12 →	+2.365	+0.301	<.001	<.001	3	4
BLCA	MUC16 →	+0.845	+0.142	.009	.007	3	4
UCEC	DNAH7 →	+1.384	+0.243	<.001	<.001	3	4
SKCM	DNAH3 →	+0.821	+0.209	<.001	<.001	3	4
SKCM	PCDHGA4 →	+2.156	+0.302	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,908 associations by consensus.

TP53 by EMC4 expression — SKCM

Explore this box plot interactively →