EMC4

Across TCGA cell cohorts, EMC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,664 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EMC4-associated GO terms across cancer lineages are Circadian sleep/wake cycle, Ubiquitin-dependent protein catabolic process via the N-end rule pathway, and Golgi lumen acidification. Each is linked with EMC4 in more than 13 cancer types. Because this analysis shows association rather than direction, both EMC4-to-partner and partner-to-EMC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Circadian sleep/wake cycle grouped by EMC4-low versus EMC4-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EMC4→partner) and Y-score (partner→EMC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Circadian sleep/wake cycle →	+0.148	+0.675	<.001	.007	3	14
BLOOD_Lymphoma	Ubiquitin-dependent protein catabolic process via the N-end rule pathway →	+0.099	+0.810	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Golgi lumen acidification →	+0.101	+0.596	<.001	.005	3	9
LUNG_NSCLC_LUAD	Melanosome localization →	+0.051	+0.437	<.001	<.001	3	7
URINARY_TRACT	Protein insertion into ER membrane by stop-transfer membrane-anchor sequence →	+0.127	+0.584	<.001	<.001	2	8
LUNG_NSCLC_LUAD	Pigment granule localization →	+0.051	+0.437	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,664 associations by consensus.

Circadian sleep/wake cycle by EMC4 expression — OESOPHAGUS

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