EMC3

Across TCGA pan-cancer cohorts, EMC3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EMC3 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EMC3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EMC3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, CCRCC, and UCEC are the cancer types where EMC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.862	0.513	<.001	39	view →
CCRCC	DFS	Median	III,IV	0.497	0.869	<.001	14	view →
UCEC	DFS	Tertile	All	0.818	1.000	.007	12	view →
PDAC	OS	Quartile	III,IV	0.729	0.324	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

EMC3–HNSC (DFS)

Open the HNSC breakdown →