EMC3

Across TCGA patient cohorts, EMC3 protein abundance is significantly associated with the RNA expression of many other genes, with 9,227 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMC3-associated genes across cancer lineages are HSPG2, CHRDL1, and C7. Each is linked with EMC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both EMC3-to-partner and partner-to-EMC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EMC3 versus HSPG2 in CCRCC, with a Pearson correlation of -0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMC3→partner) and Y-score (partner→EMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HSPG2 →	-0.890	-0.301	<.001	.002	3	5
BRCA	CHRDL1 →	-1.800	-0.440	<.001	<.001	3	4
GBM	C7 →	-1.564	-0.164	<.001	.008	2	5
UCEC	PTGIS →	-1.286	-0.451	<.001	<.001	3	4
CCRCC	ENPP2 →	-1.035	-0.249	.007	.004	3	4
BRCA	ARRB1 →	-0.691	-0.269	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,227 associations by consensus.

EMC3 vs HSPG2 — CCRCC

Explore this scatter interactively →