EMC3

Across TCGA patient cohorts, EMC3 mutation is significantly associated with the RNA expression of many other genes, with 292 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMC3-associated genes across cancer lineages are COX6CP12, HINT1P2, and MIR16-2. Each is linked with EMC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both EMC3-to-partner and partner-to-EMC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6CP12 grouped by EMC3-low versus EMC3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMC3→partner) and Y-score (partner→EMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	COX6CP12 →	+0.145	+4.513	<.001	.009	3	3
BLCA	HINT1P2 →	+0.178	+5.691	.001	<.001	3	2
BLCA	MIR16-2 →	+0.297	+5.814	<.001	.001	3	2
SKCM	LINC02079 →	+0.103	+4.680	<.001	.007	3	2
COAD	RPL22P14 →	+0.237	+4.081	<.001	.004	3	2
SKCM	RNU6-234P →	+0.451	+4.771	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 292 associations by consensus.

COX6CP12 by EMC3 expression — SKCM

Explore this box plot interactively →