EMC10

Across TCGA patient cohorts, EMC10 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMC10-associated genes across cancer lineages are Ku80, p62 Lck ligand, and Caspase-8. Each is linked with EMC10 in more than 1 cancer types. Because this analysis shows association rather than direction, both EMC10-to-partner and partner-to-EMC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by EMC10-low versus EMC10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMC10→partner) and Y-score (partner→EMC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.313	+2.183	.011	.035	3	1
UCEC	p62 Lck ligand →	+0.411	+3.009	.015	.019	3	1
UCEC	Caspase-8 →	-0.262	-3.321	.047	.010	3	1
UCEC	C-Raf →	+0.249	+3.169	<.001	.019	3	1
UCEC	Cyclin-B1 →	+0.751	+3.321	.010	.010	3	1
UCEC	Rad50 →	-0.295	-3.321	.020	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Ku80 by EMC10 expression — UCEC

Explore this box plot interactively →