EMC1

Across TCGA pan-cancer cohorts, EMC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated EMC1 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EMC1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated EMC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where EMC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.961	0.804	.014	15	view →
CCRCC	DFS	Tertile	III,IV	0.433	0.834	.004	13	view →
LUAD	OS	Tertile	III,IV	0.875	0.373	.011	10	view →
UCEC	DFS	Median	All	0.857	0.954	.031	8	view →
PDAC	OS	Median	All	0.726	0.909	.014	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

EMC1–HNSC (OS)

Open the HNSC breakdown →