EMC1

Across TCGA patient cohorts, EMC1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMC1-associated genes across cancer lineages are Notch1, eEF2, and JNK_pT183_Y185. Each is linked with EMC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EMC1-to-partner and partner-to-EMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by EMC1-low versus EMC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMC1→partner) and Y-score (partner→EMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.152	+1.861	<.001	.004	3	3
UCEC	eEF2 →	+0.285	+2.459	.014	.018	3	2
UCEC	JNK_pT183_Y185 →	-0.113	-1.415	.038	.043	3	2
UCEC	MAPK_pT202_Y204 →	-0.320	-1.584	.036	.034	3	2
UCEC	MEK1 →	+0.386	+1.999	.001	.002	3	2
UCEC	MSH2 →	-0.274	-1.821	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Notch1 by EMC1 expression — UCEC

Explore this box plot interactively →