EMB

Across TCGA pan-cancer cohorts, EMB mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EMB data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher EMB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated EMB expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, PDAC, and UCEC are the cancer types where EMB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.497	0.918	.013	7	view →
PDAC	OS	Tertile	III,IV	0.421	1.000	.013	4	view →
UCEC	DFS	Tertile	All	0.741	1.000	.030	4	view →
HNSC	OS	Median	All	0.918	0.817	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

EMB–LSCC (OS)

Open the LSCC breakdown →