EMB

Across TCGA pan-cancer cohorts, EMB mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of EMB’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where EMB mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types EMB is over-expressed in tumor, although a few such as LSCC show the opposite, repressed pattern.

PDAC, CCRCC, and LUAD are the cancer types where EMB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EMB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	+1.090	<.001	9	view →
CCRCC	All	III,IV	+0.680	<.001	9	view →
LUAD	Female	All	+0.381	<.001	8	view →
HNSC	Male	All	+0.279	<.001	8	view →
LSCC	Male	All	−0.367	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

EMB–PDAC

Open the PDAC breakdown →