EMB

Across TCGA patient cohorts, EMB mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EMB-associated genes across cancer lineages are PDCD4, ATM, and Caspase-8. Each is linked with EMB in more than 1 cancer types. Because this analysis shows association rather than direction, both EMB-to-partner and partner-to-EMB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by EMB-low versus EMB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMB→partner) and Y-score (partner→EMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.577	-2.321	.002	.033	3	2
UCEC	ATM →	-0.553	-3.459	.003	.005	3	2
UCEC	Caspase-8 →	-0.271	-3.432	.008	.005	3	2
SKCM	VHL →	-0.545	-2.321	.038	.032	3	2
UCEC	eEF2 →	+0.375	+1.807	.011	.027	3	1
UCEC	ERK2 →	+0.205	+3.321	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

PDCD4 by EMB expression — UCEC

Explore this box plot interactively →