EMB

Across TCGA cell cohorts, EMB mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EMB-associated genes across cancer lineages are PPY, HRG, and MYOD1. Each is linked with EMB in more than 1 cancer types. Because this analysis shows association rather than direction, both EMB-to-partner and partner-to-EMB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPY grouped by EMB-low versus EMB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EMB→partner) and Y-score (partner→EMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPY →	+0.120	+3.551	<.001	.009	3	1
BLOOD_Leukemia	HRG →	+0.343	+3.855	<.001	.007	3	1
BLOOD_Leukemia	MYOD1 →	+0.019	+4.507	<.001	.001	3	1
BLOOD_Leukemia	CYP1A2 →	+0.026	+4.125	.006	.008	3	1
BLOOD_Leukemia	ZIC3 →	+0.015	+4.060	<.001	.003	3	1
BLOOD_Leukemia	SERPINA12 →	+0.047	+4.060	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

PPY by EMB expression — BLOOD_Leukemia

Explore this box plot interactively →