ELP3

Across TCGA cell cohorts, ELP3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ELP3-associated genes across cancer lineages are TKTL2, TAFA1, and NEXMIF. Each is linked with ELP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELP3-to-partner and partner-to-ELP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TKTL2 grouped by ELP3-low versus ELP3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELP3→partner) and Y-score (partner→ELP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TKTL2 →	+0.043	+4.187	.001	.002	3	1
LARGE_INTESTINE	TAFA1 →	+0.280	+3.688	<.001	.002	3	1
LARGE_INTESTINE	NEXMIF →	+0.266	+4.518	<.001	<.001	3	1
SKIN	MBD3L5 →	+0.029	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	CSN1S1 →	+0.031	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	RNASE9 →	+0.025	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TKTL2 by ELP3 expression — LARGE_INTESTINE

Explore this box plot interactively →