ELP2

Across TCGA patient cohorts, ELP2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELP2-associated genes across cancer lineages are MEK1, Akt_pS473, and Akt_pT308. Each is linked with ELP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELP2-to-partner and partner-to-ELP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ELP2-low versus ELP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELP2→partner) and Y-score (partner→ELP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.518	+3.459	.001	.005	3	2
UCEC	Akt_pS473 →	+0.822	+2.459	.010	.019	3	2
UCEC	Akt_pT308 →	+0.694	+2.000	.014	.032	3	2
UCEC	PRAS40_pT246 →	+0.275	+2.584	<.001	.010	3	2
UCEC	Shc_pY317 →	-0.315	-3.459	<.001	.005	3	2
UCEC	eEF2 →	+0.526	+3.321	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

MEK1 by ELP2 expression — UCEC

Explore this box plot interactively →