ELP1

Across TCGA patient cohorts, ELP1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELP1-associated genes across cancer lineages are Cyclin-B1, Rad50, and INPP4B. Each is linked with ELP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ELP1-to-partner and partner-to-ELP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ELP1-low versus ELP1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELP1→partner) and Y-score (partner→ELP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Cyclin-B1 →	+0.638	+3.000	.011	.036	3	3
UCEC	Rad50 →	-0.214	-3.308	.009	.009	3	3
COAD	INPP4B →	-0.512	-3.313	.003	.010	3	2
UCEC	mTOR_pS2448 →	-0.105	-1.986	.039	.029	3	2
UCEC	PDCD4 →	-0.395	-2.115	.013	.016	3	2
UCEC	ASNS →	+0.283	+1.584	.021	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Cyclin-B1 by ELP1 expression — BLCA

Explore this box plot interactively →