ELP1

Across TCGA cell cohorts, ELP1 mutation is significantly associated with the mutation status of many other genes, with 3,460 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ELP1-associated genes across cancer lineages are NRXN2, DOCK4, and ATP2A1. Each is linked with ELP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ELP1-to-partner and partner-to-ELP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NRXN2 grouped by ELP1-low versus ELP1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELP1→partner) and Y-score (partner→ELP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NRXN2 →	+4.954	+4.392	.008	.008	1	5
LARGE_INTESTINE	DOCK4 →	+2.000	+4.184	<.001	<.001	1	5
CNS	ATP2A1 →	+5.277	+4.459	.005	.005	1	5
UPPER_AERODIGESTIVE_TRACT	ADAMTS2 →	+3.954	+4.906	.001	.001	1	5
BLOOD_Leukemia	BRPF1 →	+4.321	+5.285	.005	.005	1	5
CNS	PCNX2 →	+4.277	+4.584	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,460 associations by consensus.

NRXN2 by ELP1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →