ELOVL3

Across TCGA patient cohorts, ELOVL3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELOVL3-associated genes across cancer lineages are 4E-BP1, A-Raf_pS299, and FoxM1. Each is linked with ELOVL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELOVL3-to-partner and partner-to-ELOVL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ELOVL3-low versus ELOVL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELOVL3→partner) and Y-score (partner→ELOVL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.398	+3.199	.001	.009	3	2
UCEC	A-Raf_pS299 →	-0.161	-3.459	.002	.005	3	1
UCEC	FoxM1 →	+0.261	+2.000	.025	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.206	-1.986	.006	.032	3	1
UCEC	JNK2 →	+0.359	+3.469	<.001	.002	3	1
UCEC	Ku80 →	+0.332	+2.713	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

4E-BP1 by ELOVL3 expression — UCEC

Explore this box plot interactively →