ELOC

Across TCGA pan-cancer cohorts, ELOC RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated ELOC data layer compared with 1 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ELOC RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ELOC expression acts as an unfavorable survival marker, although some lineages such as CHOL and THYM show a favorable association.

UVM, HNSC, and KIRP are the cancer types where ELOC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.394	0.785	<.001	157	view →
HNSC	DFS	Median	All	0.636	0.750	<.001	126	view →
KIRP	DFS	Median	All	0.776	0.924	<.001	124	view →
KICH	DFS	Quartile	All	0.546	1.000	<.001	89	view →
LIHC	OS	Tertile	All	0.591	0.764	<.001	60	view →
BRCA	OS	Tertile	All	0.936	0.980	<.001	50	view →
ACC	DFS	Median	All	0.288	0.621	.002	48	view →
PAAD	DFS	Quartile	II,III,IV	0.301	0.650	.002	33	view →
CESC	OS	Tertile	IV	0.329	0.797	.009	26	view →
GBM	OS	Median	All	0.289	0.508	.010	21	view →
PRAD	DFS	Median	All	0.716	0.861	<.001	18	view →
CHOL	OS	Tertile	All	0.917	0.533	.015	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

ELOC–UVM (DFS)

Open the UVM breakdown →