ELOB

Across TCGA pan-cancer cohorts, ELOB mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ELOB’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ELOB mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ELOB is over-expressed in tumor.

LUAD, LSCC, and PDAC are the cancer types where ELOB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ELOB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	+0.437	<.001	9	view →
LSCC	Male	II,III,IV	+0.300	<.001	8	view →
PDAC	Female	All	+0.488	<.001	7	view →
CCRCC	All	III,IV	+0.067	.031	4	view →
COAD	Female	All	+0.135	.015	3	view →
OV	All	All	+1.724	<.001	2	view →
HNSC	All	III,IV	+0.095	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ELOB–LUAD

Open the LUAD breakdown →