ELOA

Across TCGA pan-cancer cohorts, ELOA mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ELOA’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ELOA mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ELOA is over-expressed in tumor, although a few such as PDAC and CCRCC show the opposite, repressed pattern.

LUAD, PDAC, and HNSC are the cancer types where ELOA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ELOA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.300	<.001	8	view →
PDAC	Male	All	−0.973	<.001	7	view →
HNSC	All	II,III,IV	+0.161	<.001	7	view →
CCRCC	All	II,III,IV	−0.079	.009	4	view →
LSCC	All	All	+0.084	.003	3	view →
COAD	Male	III,IV	+0.143	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ELOA–LUAD

Open the LUAD breakdown →