ELN

Across TCGA patient cohorts, ELN protein abundance is significantly associated with the RNA expression of many other genes, with 15,535 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ELN-associated genes across cancer lineages are FBLN5, MFAP4, and ADH1B. Each is linked with ELN in more than 8 cancer types. Because this analysis shows association rather than direction, both ELN-to-partner and partner-to-ELN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ELN versus FBLN5 in CCRCC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELN→partner) and Y-score (partner→ELN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FBLN5 →	+1.384	+0.568	.003	.005	3	9
CCRCC	MFAP4 →	+2.375	+0.734	.001	.003	3	9
OV	ADH1B →	+2.379	+1.190	<.001	<.001	3	9
CCRCC	SRPX →	+1.355	+0.839	.004	<.001	3	8
LUAD	SGCA →	+0.985	+0.781	<.001	<.001	3	8
BRCA	MGP →	+1.632	+0.603	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,535 associations by consensus.

ELN vs FBLN5 — CCRCC

Explore this scatter interactively →