ELN

Across TCGA cell cohorts, ELN mutation is significantly associated with the RNA expression of many other genes, with 145 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ELN-associated genes across cancer lineages are SCGB3A2, OCM2, and TMEM174. Each is linked with ELN in more than 1 cancer types. Because this analysis shows association rather than direction, both ELN-to-partner and partner-to-ELN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB3A2 grouped by ELN-low versus ELN-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELN→partner) and Y-score (partner→ELN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SCGB3A2 →	+0.080	+5.614	<.001	.002	3	1
BREAST	OCM2 →	+0.067	+4.781	<.001	.003	3	1
BREAST	TMEM174 →	+0.011	+4.672	.001	.002	3	1
BREAST	OR52E8 →	+0.039	+4.199	<.001	.007	3	1
BREAST	IQCF2 →	+0.032	+4.781	<.001	.003	3	1
BREAST	KRTAP10-8 →	+0.032	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 145 associations by consensus.

SCGB3A2 by ELN expression — PANCREAS

Explore this box plot interactively →