ELMO2

Across TCGA patient cohorts, ELMO2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELMO2-associated genes across cancer lineages are ATM, Notch1, and PCNA. Each is linked with ELMO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ELMO2-to-partner and partner-to-ELMO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ELMO2-low versus ELMO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELMO2→partner) and Y-score (partner→ELMO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.475	-2.459	.002	<.001	3	3
UCEC	Notch1 →	+0.217	+2.070	<.001	.001	3	2
UCEC	PCNA →	+0.264	+2.321	<.001	<.001	3	2
UCEC	PRDX1 →	+0.198	+2.321	.005	.005	3	2
UCEC	STAT3_pY705 →	-0.305	-1.990	<.001	.009	3	2
UCEC	14-3-3_beta →	-0.079	-1.673	.023	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ATM by ELMO2 expression — UCEC

Explore this box plot interactively →