ELMO1

Across TCGA pan-cancer cohorts, ELMO1 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated ELMO1 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher ELMO1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ELMO1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

THYM, KIRP, and BLCA are the cancer types where ELMO1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
KIRP	DFS	Median	All	0.040	0.896	<.001	33	view →
BLCA	OS	Median	All	0.082	0.688	<.001	24	view →
COAD	OS	Median	IV	0.056	0.659	<.001	12	view →
UCEC	DFS	Median	All	0.901	0.615	.017	12	view →
READ	DFS	Median	All	0.182	0.798	.010	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SCLC	DFS	Median	III,IV	0.137	0.546	.042	6	view →
LIHC	DFS	Median	All	0.148	0.555	.023	6	view →
BRCA	DFS	Median	All	0.800	0.950	.035	4	view →
GBM	DFS	Median	All	0.799	0.245	.031	3	view →
LUAD	DFS	Median	II,III,IV	0.781	0.225	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

ELMO1–THYM (OS)

Open the THYM breakdown →