ELMO1

Across TCGA pan-cancer cohorts, ELMO1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ELMO1 data layer compared with 23 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ELMO1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ELMO1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

HNSC, LUAD, and COAD are the cancer types where ELMO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.594	0.864	.015	15	view →
LUAD	DFS	Median	All	0.772	0.517	.002	14	view →
COAD	DFS	Tertile	II,III,IV	0.870	1.000	.040	12	view →
CCRCC	DFS	Quartile	II,III,IV	0.933	0.402	<.001	12	view →
PDAC	OS	Median	III,IV	0.326	0.829	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ELMO1–HNSC (DFS)

Open the HNSC breakdown →