ELMO1

Across TCGA cell cohorts, ELMO1 mutation is significantly associated with the RNA expression of many other genes, with 297 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ELMO1-associated genes across cancer lineages are NOL9, TNK1, and OVCA2. Each is linked with ELMO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELMO1-to-partner and partner-to-ELMO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOL9 grouped by ELMO1-low versus ELMO1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELMO1→partner) and Y-score (partner→ELMO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NOL9 →	+0.620	+3.169	.005	.009	3	2
LARGE_INTESTINE	TNK1 →	+0.700	+3.064	.005	.009	3	2
LARGE_INTESTINE	OVCA2 →	+0.488	+3.714	.002	<.001	3	2
LUNG_NSCLC_LUAD	GTSF1L →	+0.021	+2.637	.004	.007	3	1
LUNG_NSCLC_LUAD	CSH1 →	+0.040	+2.665	<.001	.004	3	1
LUNG_NSCLC_LUAD	KLHL40 →	+0.013	+3.481	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 297 associations by consensus.

NOL9 by ELMO1 expression — LARGE_INTESTINE

Explore this box plot interactively →