ELL3

Across TCGA patient cohorts, ELL3 mutation is significantly associated with the RNA expression of many other genes, with 506 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELL3-associated genes across cancer lineages are RPS4Y2, TIMM22, and EIF4A1P9. Each is linked with ELL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELL3-to-partner and partner-to-ELL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS4Y2 grouped by ELL3-low versus ELL3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELL3→partner) and Y-score (partner→ELL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RPS4Y2 →	+0.044	+3.996	<.001	.005	3	2
UCEC	TIMM22 →	+0.453	+3.428	.001	.004	3	2
UCEC	EIF4A1P9 →	+0.158	+2.706	<.001	.007	3	2
UCEC	UBBP3 →	+0.432	+2.192	.009	.003	3	2
COAD	FTLP18 →	+0.082	+5.149	<.001	.001	3	2
CESC	RNU6-840P →	+0.823	+4.450	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 506 associations by consensus.

RPS4Y2 by ELL3 expression — CESC

Explore this box plot interactively →