ELL3

Across TCGA patient cohorts, ELL3 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELL3-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and ETS-1. Each is linked with ELL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELL3-to-partner and partner-to-ELL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ELL3-low versus ELL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELL3→partner) and Y-score (partner→ELL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.068	+3.479	<.001	.002	3	2
UCEC	eEF2 →	+0.421	+2.000	.009	.032	2	2
UCEC	ETS-1 →	+0.288	+2.999	.044	.035	3	1
UCEC	MSH2 →	-0.361	-2.000	<.001	.032	3	1
UCEC	p62 Lck ligand →	+0.402	+3.169	.006	.018	3	1
UCEC	PDK1 →	+0.097	+3.013	.046	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Caspase-7-cleavedD198 by ELL3 expression — UCEC

Explore this box plot interactively →