ELK4

Across TCGA patient cohorts, ELK4 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELK4-associated genes across cancer lineages are eIF4E, JNK2, and MEK1. Each is linked with ELK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELK4-to-partner and partner-to-ELK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ELK4-low versus ELK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELK4→partner) and Y-score (partner→ELK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.186	+2.183	.043	.033	3	1
UCEC	JNK2 →	+0.272	+2.807	.001	.003	3	1
UCEC	MEK1 →	+0.339	+2.115	.034	.019	3	1
UCEC	p62 Lck ligand →	+0.488	+3.906	<.001	<.001	3	1
UCEC	p70-S6K_pT389 →	-0.190	-2.115	.022	.019	3	1
UCEC	AMPK_pT172 →	+0.390	+2.459	.030	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eIF4E by ELK4 expression — UCEC

Explore this box plot interactively →