ELK1

Across TCGA patient cohorts, ELK1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELK1-associated genes across cancer lineages are Tuberin, 14-3-3_beta, and FOXO3a_pS318_S321. Each is linked with ELK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELK1-to-partner and partner-to-ELK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by ELK1-low versus ELK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELK1→partner) and Y-score (partner→ELK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.363	+2.115	<.001	.016	3	2
UCEC	14-3-3_beta →	-0.092	-2.432	.012	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.090	-1.405	.049	.043	3	1
UCEC	ACC1 →	+0.346	+2.335	.009	.018	3	1
UCEC	INPP4B →	-0.252	-1.874	.034	.049	3	1
UCEC	Ku80 →	+0.234	+1.713	.006	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Tuberin by ELK1 expression — UCEC

Explore this box plot interactively →