ELK1

Across TCGA cell cohorts, ELK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,031 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ELK1-associated GO terms across cancer lineages are Spindle elongation, Spindle midzone assembly, and Growth hormone secretion. Each is linked with ELK1 in more than 14 cancer types. Because this analysis shows association rather than direction, both ELK1-to-partner and partner-to-ELK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle elongation grouped by ELK1-low versus ELK1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ELK1→partner) and Y-score (partner→ELK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Spindle elongation →	+0.237	+0.700	<.001	.001	3	15
KIDNEY	Spindle midzone assembly →	+0.201	+0.799	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Growth hormone secretion →	+0.155	+1.152	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Regulation of mitotic metaphase/anaphase transition →	+0.136	+0.994	<.001	<.001	3	13
BREAST	Negative regulation of heterochromatin organization →	+0.131	+1.288	<.001	<.001	3	13
BREAST	Regulation of heterochromatin formation →	+0.111	+1.274	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,031 associations by consensus.

Spindle elongation by ELK1 expression — KIDNEY

Explore this box plot interactively →