ELK1

Across TCGA cell cohorts, ELK1 mutation is significantly associated with the drug of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ELK1-associated genes across cancer lineages are Dihydrorotenone, TAK-715, and WYE-125132. Each is linked with ELK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ELK1-to-partner and partner-to-ELK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dihydrorotenone grouped by ELK1-low versus ELK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELK1→partner) and Y-score (partner→ELK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Dihydrorotenone →	+0.421	+2.649	.041	.046	3	1
LARGE_INTESTINE	TAK-715 →	+0.516	+2.786	.012	.037	3	1
LARGE_INTESTINE	WYE-125132 →	+0.555	+2.652	.029	.045	3	1
LARGE_INTESTINE	PF-00299804 →	+0.674	+2.652	.003	.045	3	1
LARGE_INTESTINE	Mirin →	+0.377	+2.646	.047	.047	2	1
LARGE_INTESTINE	AGI-6780 →	+0.414	+2.646	.032	.047	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Dihydrorotenone by ELK1 expression — LARGE_INTESTINE

Explore this box plot interactively →